Biotechnology, Public Health, and National Security

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    • DNA detection and analysis platforms. As we are seeing in the anthrax scare, we need to be able to rapidly determine whether a person has been exposed to an infectious agent, and we also need capabilities for detecting these agents in the environment. Some devices have been developed already for these purposes, and others are in the pipeline.
      • DARPA provided funding for a portable detection device that can analyze DNA from a sample to detect the presence of a pre-selected infectious agent in 30 minutes. Such devices speed diagnosis and allow it to be performed anywhere, without the need to ship samples to labs.
      • Portable biosensors have been developed to detect the exact DNA sequences of pathogens in the atmosphere. Such rapid detection systems provide the precious time necessary for evacuation, vaccination or other prophylactic measures necessary to save lives.
    • DNA detection and analysis platforms. As we are seeing in the anthrax scare, we need to be able to rapidly determine whether a person has been exposed to an infectious agent, and we also need capabilities for detecting these agents in the environment. Some devices have been developed already for these purposes, and others are in the pipeline.
    • Other approaches:
      • Remediation technologies. Specialized enzymes can be sprayed over contaminated areas, rendering infectious agents harmless.
      • Barrier strategies. These strategies center on the creation of molecular barriers to infection. One company, for example, is developing molecules that adhere to entry sites on mucosal membranes to prevent the absorption of viruses and bacteria into the bloodstream.
    • Although the spotlight is on bioterrorism, the biotechnology industry is developing products that may have utility in treating injuries and illness resulting from conventional attacks as well. Artificial skin products, for example, were deployed to treat burn victims of the September 11 attacks. Other biotechnology products with potential applications in an emergency include blood products (such as blood replacement and purification products now in development) and surgical products. Under battlefield conditions, soldiers are vulnerable to naturally occurring infections such as influenza. The biotechnology industry is addressing such illnesses with vaccines (including some under development that could be taken orally or as a nasal spray), antivirals and antibiotics.
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