Therapeutic Newsletters

Focus on Cardiology, Pulmonology, and Blood
NHLBI study genetic data does not improve anticoagulation control with warfarin. Combining genetic data with clinical information to determine the initial dosage of the blood thinner warfarin was no more effective in achieving stable anticoagulation than using only clinical information, according to the NIH-funded Clarification of Optimal Anticoagulation through Genetics (COAG) clinical trial... Read More

Focus on Nephrology, Endorinology, Metabolism, and Gastroenterology
NIDDK gene hastens kidney disease progression in African-Americans. A gene variant common in African-Americans predicts that people with that gene who also have chronic kidney disease (CKD) are twice as likely to progress to kidney failure as African-Americans without the high-risk gene and white people with CKD. People with the high-risk gene also tend to lose kidney function at twice the rate of those without the gene, according to the research, which was funded by the National Institutes of Health... Read More

Focus on Neurology and CNS
NINDS funded NIH network revolutionizes stroke clinical research. A network of 25 regional stroke centers working with nearby satellite facilities will span the country, have teams of researchers representing every medical specialty needed for stroke care and will address the three prongs of stroke re-search: prevention, treatment and recovery. “The new system is intended to streamline stroke research, by centralizing approval and review, lessening time and costs of clinical trials, and assembling a comprehensive data sharing system,” said Petra Kaufmann, M.D., the associate director for clini-cal research at the National Institute of Neurological Disorders and Stroke (NINDS)... Read More

Focus on Oncology
NCI sponsored clinical trial of personalized vaccine for brain tumor shows promise. Patients with recurrent glioblastoma multiforme (GBM) treated with an experimental vaccine made from the patient's own re-sected tumor tissue showed an improved survival rate compared with historical patients who received the standard of care alone, according to an analysis of a phase 2 trial of this vaccine that was recently published in the journal Neuro-Oncology and accompanied by an editorial highlighting the importance of the trial... Read More

Focus on Rheumatology, Inflammation, Anesthesia, and Pain
NIAMS funded study finds gut microbes linked to rheumatoid arthritis. The presence of a specific type of gut bacteria correlates with rheumatoid arthritis in newly diagnosed, untreated people. The finding suggests a potential role for the bacteria in this autoimmune disease. Rheumatoid arthritis is a chronic inflammatory disorder that can cause pain, swelling, stiffness, and loss of function in the finger, wrist, and other joints. It occurs when the immune system mistakenly attacks the body’s own tissue, such as the membranes that line the joints... Read More

Focus on Allergy, Infectious Disease, and Antiviral
NIAID launches trial of investigational genital herpes vaccine. Researchers have launched an early-stage clinical trial of an investigational vaccine designed to prevent genital herpes disease. The National Institute of Allergy and Infectious Diseases (NIAID) is sponsoring the Phase I trial. Most genital herpes cases are caused by infection with herpes simplex virus type 2 (HSV-2); however, herpes simplex virus type 1 (HSV-1) can also cause genital herpes. An estimated 776,000 people in the United States are infected with HSV-2 or HSV-1 each year. There is no vaccine to prevent genital herpes... Read More