Therapeutic Newsletters

Focus on Cardiology, Pulmonology, and Blood
NHLBI STUDY: Adults stop anti-rejection drugs after partial stem-cell transplant reverses sickle cell disease. Half of patients in a trial have safely stopped immunosuppressant medication following a modified blood stem-cell transplant for severe sickle cell disease, according to a study in the July 1 issue of the Journal of the American Medical Association. The trial was conducted at the National Institutes of Health’s Clinical Center in Bethesda, Maryland, by researchers from NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute (NHLBI)... Read More

Focus on Nephrology, Endorinology, Metabolism, and Gastroenterology
NIDDK STUDY: Gene type confers 26 percent chance of early celiac sign by age 5. More than one quarter of children with two copies of a high-risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5. The findings are from The Environ-mental Determinants of Diabetes in Youth consortium (TEDDY)... Read More

Focus on Neurology and CNS
NINDS scientists take a totally tubular journey through brain cells. Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain’s protective barrier, a study in mice indicates. This finding could ultimately lead to new ways to bring about the death of the tumor, as therapies may be able to reach these deadly cells at an earlier time point than was previously thought possible. This research was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH... Read More

Focus on Oncology
NCI study identifies novel genomic changes in the most common type of lung cancer. Researchers from The Cancer Genome Atlas (TCGA) Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer. Knowledge of these genomic changes may expand the number of possible therapeutic tar-gets for this disease and potentially identify a greater number of patients with treatable mutations be-cause many potent cancer drugs that target these mutations already exist... Read More

Focus on Rheumatology, Inflammation, Anesthesia, and Pain
NIAMS scientists identify gene linked to fatal inflammatory disease in children. Investigators have identified a gene that underlies a very rare but devastating autoinflammatory condition in children. Several existing drugs have shown therapeutic potential in laboratory studies, and one is currently being studied in children with the dis-ease, which the researchers named STING-associated vasculopathy with onset in infancy (SAVI). The research was done at the National Institute of Arthritis and Musculoskeletal and Skin Dis-eases (NIAMS)... Read More

Focus on Allergy, Infectious Disease, and Antiviral
NIAID STUDY: scientists uncover features of antibody-producing cells in people infected with HIV. By analyzing the blood of almost 100 treated and untreated HIV-infected volunteers, a team of scientists has identified previously unknown characteristics of B cells in the con-text of HIV infection. B cells are the immune system cells that make anti-bodies to HIV and other pathogens. The findings augment the current understanding of how HIV disease develops and have implications for the timing of treatment. Researchers at the National Institute of Allergy and Infectious Dis-eases (NIAID), part of the National Institutes of Health, led the study... Read More