Truwl accelerates life science discovery by helping users optimize, share, and use computational methods to uncover insights in genomics data and validate results. Inspired by the principles of accessibility, sharing, and collaboration, Truwl connects computational tool and workflow developers and their methods with end users within an organization or openly on the internet. Truwl aims to be the go-to site for organizations to share methods, streamline computational research, and interact with community members. Among other projects, the company is working with the Encyclopedia of DNA Elements (ENCODE) data coordination center to provide comprehensive community access to computational workflows developed and used by the ENCODE consortium through the Truwl web interface for launching and monitoring workflows. Truwl is also beginning to work with diagnostic laboratories to enable faster workflow optimization, validation, and ongoing NGS workflow performance monitoring.