It is well documented that clinical trials in the U.S. lack appropriate diverse representation. Significant attention has been focused on the inclusion of participants in research that reflect underrepresented populations and/or those likely to use the intervention. Among the many initiatives to increase diversity, early integration of input from the intended population can strengthen the validity of the research questions, accessibility of the study, ease with which an individual can fulfill participation requirements, and eventual generalizability of the findings. Further, establishing long-term engagement partnerships can aid in building trust among patient communities. In this session we discuss engagement strategies and health literacy best practices in the development of clear participant-facing communications that facilitate understanding, support autonomy, and overall, inclusion and access to under-represented populations.