Damage caused by opioid misuse and addiction reaches across every domain, from lost productivity and economic opportunity, to intergenerational and childhood trauma, to major strains on community resources. Fresh thinking and radical solutions are desperately needed. NIH HEAL has called “all hands on deck” to address the opioid crisis and a diversity of approaches are being taken towards new treatments and recovery tools. Could psychedelics be employed as is or altered to provide anti-addiction remedies? Could cutting-edge “organ-on-a-chip” nanotechnology accelerate scientific discovery and enable better preclinical testing platforms -- without the use of animals? Could 24/7 support through a digital app and recovery tools including "behavioral nudging" help recovering addicts stay on track and become thriving members of society?