Momotaro-Gene Inc.

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Momotaro-Gene is a clinical stage biotech company conducting two Phase IIa trials, localized prostate cancer and mesothelioma, in the US. We are a cancer gene therapy using REIC/Dkk-3 gene isolated and cloned at Okayama University, Japan. The adenovirus vector carrying the human REIC/Dkk-3 gene (Ad-REIC) induces cancer-selective apoptosis and enhances anti-tumor immunity. Cancer selective apoptosis occurred due to ER stress and REIC protein induces the patients' own cancer CTL and also down-regulates T-regulatory cell.
One CRPC patient with lymph node metastases has been in complete remission for more than 7 years. This therapy is highly minimally invasive with only the fever at the night of injection.
Our next target is malignant mesothelioma, which does not have a good drug at all. Mouse model at Baylor College in the US showed great promise for the combination therapy with PD-1 inhibitor. Our P2 started last September and three patients has been treated so far.
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Momotaro-Gene Inc.