The downstream purification system SymphonXTM uses a disposable, generic flow path to operate multiple downstream process unit operations (e.g. Chromatography, Tangential Flow Filtration (TFF), Single-Pass TFF, Viral Inactivation and Viral Filtration). This presentation outlines the functional flexibility of the system and its advanced Buffer Management capabilities (in-line conditioning and in-line dilution), all contained within one propriety multi-functional hardware, flow path and operating software and its deployment in a continuous process. We present data from a successful non-GMP operation of multiple connected, integrated SymphonXTM skids in FUJIFILM Diosynth Biotechnologies’ continuous monoclonal antibody production platform, MaruXTM. The SymphonX™ design simplifies the single-use consumable supply chain, allows plug and play flexibility across all downstream unit operations and provides a generic operator interface to de-risks execution of complex continuous bioprocessing operations in a multi-product facility.