About Dr. Marks: I am a computational biologist interested in how to read the genome and interpret its variation. Recently, we have used evolutionary couplings determined from genomic sequencing to accurately protein 3D structure from sequences alone, including the experimentally challenging transmembrane proteins. Continuing from this my lab aims to predict alternative conformations and plasticity of proteins, and the consequences of protein genetic variation on pharmacological intervention. In a complementary approach, we are examining on the effect of drugs on patients and cell lines by bringing together large bodies of data from multiple perturbations and thousands of cancer patient tissues.
12:45 PM - 1:30 PM (EDT)
Monday, June 14