Creating an equitable and inclusive biotech ecosystem that fosters participation of individuals from underrepresented groups is critical to unlocking innovation. Recognizing this, the National Institute on Aging (NIA) launched programs to increase diversity at all stages of entrepreneurship, from career development awards to the launching of a challenge prize in 2022 designed to provide both mentoring and pilot funding to foster diversity and advance longevity innovation. BIO, Medtech Color, several investment groups including Deerfield, and others have launched powerful initiatives to increase diversity within the ecosystem. The National Institute on Minority Health and Health Disparities (NIMHD) and venture capital firms have put considerable effort into developing innovations that improve the health and livelihood of diverse populations. Innovative biotech firms such as Obatala Sciences have navigated the landscape and advancing innovations that drive diversity in research. These efforts are poised to break barriers and spur innovation to extend healthy aging and combat Alzheimer’s Disease and Related Dementia.