SymphonXTM: Advancing biomanufacturing capabilities with a next generation single use technology solution

The in-house developed downstream purification system SymphonX^TM uses a disposable, generic flow path to operate multiple downstream process unit operations (e.g. Chromatography, Tangential Flow Filtration (TFF), Single-Pass TFF, Viral Inactivation and Viral Filtration).  This presentation outlines the functional flexibility of the system, its advanced buffer management capabilities (in-line conditioning and in-line dilution) and operational capability improvements.  The SymphonX™ design simplifies the single-use consumable supply chain, allows plug and play flexibility across all downstream unit operations and provides a generic operator interface to de-risk execution of complex batch and continuous bioprocessing operations in a multi-product facility.